LaRosa,

Hello! Welcome to the community; I am so glad you found this site. I have not been on Brinsupri nor have heard of a similar issue thus far. Brinsupri has only been on the market for over one year. Have you discussed this with your Pulmonologist? Perhaps, they will want to increase the dose to 25mg to see if it helps since the 10 mg was helping you initially. Our bodies get accustomed to a medication and often an increase in dose is needed for some medications. Please let us know what your Pulmonologist suggests. We look forward to hearing back from you. 

Welcome to our community - we're really glad you're here! 

Welcome La Rosa! We are so happy to have you here! 

Hi LaRosa. 

I haven't heard of those in our patient community feeling as though Brinsupri is less effective over time. I would talk with your health care provider about your concerns. It is possible, as Katie mentioned, that you may need to go up to the higher dose. Also, the specialty pharmacy that is distributing your Brinsupri should have additional information. You can lean on their patient support team for questions like these. They are a wealth of information. Keep us posted on your journey. 

I have also  I started and continue on the higher dosage.  It has helped.  I had the best winter I ever had but even though I woud say I still have a lot of mucus and coughing my breathing is improved.  But I find that alot of how my mucus and coughing is related to weather.  When the barameter and humidity change so does my production and I have come up with a good routine.  I still say it is helpful. Hang in there.

La Rosa,

 I have been taking 25 mg of Brinsupri for about 9 mos. I too found it quite helpful initially with a marked reduction in lung secretions and coughing. About a month ago I began to notice that it didn’t seem to be working as well. I’m not back to square one, I do think it’s still helping, just not as much as before. I guess time will tell if this trend continues…

Cjack

Hi LaRosa! I’m new here too. 😊 I’ve been on the 25 mg for 13 months. I haven’t experienced what you describe. Being on 10mg gives you the option of increasing to 25mg if your pulmonologist thinks it would benefit you.  We all are having different reactions and responses to this medication. It has its challenges, but like you, after more than 30 years with Bronchiectasis, it is so amazing to have some change for the better. 
Maggie 

LaRosa,

I had a visit with my pulmonologist yesterday and I brought up this very issue. He responded that because Brinsupri is so new, it isn’t known yet whether the reduction in symptoms fades over time for a significant number of patients. He noted that most of his patients on Brinsupri have not reported this but also that some never reported a reduction in symptoms to begin with. He also reminded me that the efficacy of the drug is based on research that shows it decreases the number of bronchiectasis flares. It’s main purpose is as a maintenance drug to reduce exacerbations. He called day-to-day symptom reduction a “bonus” that many, but not all, patients report. 

I hope this is helpful information—it was for me.

Best,

Cjack

LaRosa,

Hello! I am so glad to read that you are experiencing improvement with Brinsupri. We are grateful for you sharing your results with the community. Have a pleasant evening. 😍