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Rifampin and Azithro RX -any suggestions on diet & timing?

In: Treatments & Medications
6 269
PJ

Hello,

I will be starting Rifampin and Azithro, but chose not to add the Amikacin at this point. (they only offered the IV and am concerned about the side effects and it makes it very difficult to work full time and get to the hospital for the IV infusion 3x week). 

Should I be taking a probiotics as well to help maintain healthy gut bacteria?

Is there a suggested schedule of when/how to take the meds + probiotic? 

Any other foods I should increase or remove from my diet to help? (I do not drink alcholol and do not take other meds other than daily vitamins).


I appreciate any help or feedback as this is a bit scary to do.


Thank you,

Patricia

Latest Activity: October 15, 2026
6 Replies

Replies

K

Patricia,

Hello! I am sure that it is a "little scary," to say the least, to take these antibiotics for an extended period.

Rifampin is best taken at night, 1-2 hours before you go to bed. Rifampin will discolor your urine to an orange color. Rifampin has many drug interactions, so make sure that your supplements are reviewed by your doctor or pharmacist.  I am glad that you don't drink alcohol since this is one drug that absolutely does not mix well with any alcohol.

Azithromycin can be taken with or without food- I always prefer to take it with food. Discuss any antacids you may be taking with your pharmacist while taking this antibiotic.

Yes, it is recommended to take probiotics, but not within a 2-hour timeframe of taking your antibiotics.  Do you have access to a registered dietitian to assist you on your journey?  Dietitians are covered by some insurance plans. I assume that your healthcare provider informed you that you will need regular lab work while on these drugs.  I hope that the initiation of taking these drugs goes smoothly. Please check in to let us know how you are doing. 

Latest Activity: September 16, 2026

Comments

PJ

Thank you! Yes, I will have regular labs along the way. I appreciate the feedback & will look into a nutritionist. 

Latest Activity: September 17, 2026
K

Patricia,

You are most welcome! I have been down the road that you are now traveling. Please reach out at anytime with any questions you may have. 

Latest Activity: September 17, 2026
PJ

I do have a question, if I may :) how do I find a nutrionist? i am looking both on the Northwestern Medicine website (my doctors are in this medical group) and in my insurance. The nutrionists that come up are MD's specializing in Pediatrics, Diabetes, or other Gastroenterology conditions and that doesn't seem to be what I'd be looking for. Any help on how to find the right type of nutritionist would be great! 

Latest Activity: September 17, 2026
K

Patricia,     Great question- you want a personal referral from your Pulmonologist, gastroenterologist if possible. You want a registered dietitian who truly understands the needs of an NTM patient. It may take sometime to find someone in your area but it is certainly worth the time and effort to find the right person. I wish that I had found the right dietitian early on in my diagnosis. Preventative measures are far easier to deal with than curative measures. Have you watched any of the videos on Nutrition by Michelle MacDonald? https://m.youtube.com/watch?v=30L2Ha4W_Nk&ra=m

Latest Activity: September 17, 2026
PJ

Hi Katie,

I met with my ID doctor since starting Rifampin & Azithro (it was one of the partners in the medical group I had not yet met). He suggested a totally different drug combination: stop the Rifampin & Azithro and start clofazimine and omadacycline and he talked me into adding the IV amikacin. Does this change up occur? Do you have any experience or working knowledge of these 2 new (to me) drugs and side effects? 

I'm a bit emotionally overwhelmed b/c it took me so long to accept and start the Rifampin/Azithro and NOT do IV amikacin and I've felt alot less congestion and better overall and now to have a whole switch up. It seems like the doctors don't talk with each other yet they are partners. 

It's also a bit difficult because they don't quite understand how much it weighs on a patient (or just me) to go to the hospital 3x/week while working full time. It adds quite a bit of stress into those days and stress doesn't help overall health. It is alot to juggle and a switch up is confusing on why one doctor recommends some meds and a different doctor goes in a different direction. 

I am grateful for the meds and medical teams! It's just alot.


Thank you for any insights you can share.


Patricia


Latest Activity: October 13, 2026
K

Patricia,

Hello! Changes in drug regime do occur if one health care provider feels a different regime would be more effective for you. They should explain the rationale behind their decision. Can you email them through the portal to ask them for an explanation.

Did they explain possible side effects of these drugs?

Yes. this is an overwhelming and frightening process, to say the veryleast. It is alot to juggle going to a hospital 3x a week while working full-time. 

You can contact us at-if you wish to email or speak: contactus@bronchandntm.org or call us at  833-411-5864. Katie 


Latest Activity: October 13, 2026
D

I hope you're able to get access to a nutritionist. If not, even asking your doctor some of these questions might help. Sending well wishes!

Latest Activity: September 17, 2026

Comments

PJ

Thank you Delia!

Latest Activity: September 17, 2026
A

Hi Patricia,

We have a couple of resources you may find helpful:

  • Nutrition & Bronchiectasis : In this webinar, Michelle MacDonald discusses nutrition challenges associated with bronchiectasis and NTM, including ways to add foods that support prebiotics, probiotics, and postbiotics.
  • Coffee Break: Nutrition-Related Labs: This episode Michelle MacDonald covers nutrition-related lab tests and ways to support your health needs with vitamins and supplements.

I hope you find these helpful!

Latest Activity: October 14, 2026

Comments

PJ

Thank you!

Latest Activity: October 15, 2026
K

Patricia,

Hello! Allysa posted two great links in another post. Probiotics are to be taken 2 hours before or after taking the antibiotics. As mentioned previously, a registered dietitian could really be of great assistance on your journey. Wishing you the best as you begin your new treatment. 

Latest Activity: October 14, 2026

Comments

PJ

Thank you so much! Having support like this is so helpful!

Latest Activity: October 15, 2026
K

Patricia,

Hello! Allysa posted two great links in another post. Probiotics are to be taken 2 hours before or after taking the antibiotics. As mentioned previously, a registered dietitian could really be of great assistance on your journey. Wishing you the best as you begin your new treatment. 

Latest Activity: October 14, 2026
K

Patricia,

Hello! Allysa posted two great links in another post. Probiotics are to be taken 2 hours before or after taking the antibiotics. As mentioned previously, a registered dietitian could really be of great assistance on your journey. Wishing you the best as you begin your new treatment. 

Latest Activity: October 14, 2026

It is not our intention to serve as a substitute for medical advice and any content posted should not be used for medical advice, diagnosis or treatment. We make every effort to support our members, our medical professionals cannot and will not provide a diagnosis or suggest a specific medication; those decisions should be left to your personal medical team. While we encourage individuals to share their personal experiences with Bronchiectasis and NTM, please consult a physician before making changes to your own Bronchiectasis and NTM management plan.

Community posts are monitored by the 360social Community Manager, as well as staff respiratory therapists, educators, and other medical professionals.

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